Article

<i>kri-1/KRIT1</i> restrains <i>skn-1/NRF2</i> activation to promote innate immune and lipid homeostasis

2026-05-18

Abstract excerpt

<h4>ABSTRACT</h4> Animals must differentially allocate essential metabolic resources in response to changing environmental conditions to ensure reproductive success. For example, adult C. elegans coordinate innate immune defenses during infection and also allocate fat stores to the germline, each of which are required for evolutionary fitness. The genetic mechanisms that integrate resource allocation and host de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b2d2f4d1-577a-5cab-a9e9-cc9454578b1e
DOI: 10.64898/2026.05.15.725342

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>kri-1/KRIT1</i> restrains <i>skn-1/NRF2</i> activation to promote innate immune and lipid homeostasisDOI 10.64898/2026.05.15.725342Read

Germ-cell loss extends C. elegans life span through regulation of DAF-16 by kri-1 and lipophilic-hormone signaling.Semantic proximity Read

Krüppel-like factor 1 acts upstream of the SKN-1/Nrf transcription factors to modulate oxidative stress, lipid homeostasis and longevitySemantic proximity Read

The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.Semantic proximity Read

LIPL-1 and LIPL-2 are TCER-1-regulated Lysosomal Lipases with Distinct Roles in Immunity and FertilitySemantic proximity Read

The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in <i>C. elegans</i>Semantic proximity Read

Genome-wide temporal gene expression reveals a post-reproductive shift in the nematode <i>C. briggsae</i>Semantic proximity Read

Activated SKN-1 alters the aging trajectories of long-lived C. elegans mutantsSemantic proximity Read

Activated SKN-1 alters the aging trajectories of long-lived Caenorhabditis elegans mutants.Semantic proximity Read

The TWK-26/KCNK3 potassium channel and FLR-4 protein kinase coordinate nutrient absorption in the <i>C. elegans</i> intestineSemantic proximity Read

Dietary <i>S. maltophilia</i> promotes fat storage by enhancing lipogenesis and ER-LD contacts in <i>C. elegans</i>Semantic proximity Read

DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.Semantic proximity Read

PRY-1/AXIN signaling regulates lipid metabolism in <i>Caenorhabditis elegans</i>Semantic proximity Read