Article

The F-box protein FBXL-5 governs vitellogenesis and lipid homeostasis in <i>C. elegans</i>

2024-04-22

Abstract excerpt

<h4>ABSTRACT</h4> The molecular mechanisms that govern the metabolic commitment to reproduction, which often occurs at the expense of somatic reserves, remain poorly understood. We identified the C. elegans F-box protein FBXL-5 as a negative regulator of maternal provisioning of vitellogenin lipoproteins, which mediate the transfer of intestinal lipids to the germline. Mutations in fbxl-5 partially suppress the...

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Literature Corpus work: 13f3d9ee-dd60-55cd-9ecc-3255e3f4c758
DOI: 10.1101/2024.04.18.590113

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