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Article

The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.

Nature communications - 17 Jul 2019

Amrit Francis R G, Naim Nikki, Ratnappan Ramesh, Loose Julia, Mason Carter, Steenberge Laura, McClendon Brooke T, Wang Guoqiang, Driscoll Monica, Yanowitz Judith L, Ghazi Arjumand

Abstract excerpt

Stress resistance and longevity are positively correlated but emerging evidence indicates that they are physiologically distinct. Identifying factors with distinctive roles in these processes is challenging because pro-longevity genes often enhance stress resistance. We demonstrate that TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, has opposite effects...

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Identifiers

PMID: 31316054
DOI: 10.1038/s41467-019-10759-z
PMCID: PMC6637209

Genes

TCERG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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