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Article

The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic <i>Trypanosoma cruzi</i> infection

2023-07-12

Abstract excerpt

<h4>Background</h4> Chagas disease, chronic infection with Trypanosoma cruzi , mainly manifests as cardiac disease. However, the liver is important for both controlling parasite burdens and metabolizing drugs. Notably, high doses of anti-parasitic drug benznidazole (BNZ) causes liver damage. We previously showed that combining low dose BNZ with a prototype therapeutic vaccine is a dose sparing strategy that effe...

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Literature Corpus work
b2b488ad-a2c4-5e70-b95a-95b0c78fe8ed
DOI
10.1101/2023.07.11.548497
Open publication

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The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic <i>Trypanosoma cruzi</i> infectionDOI 10.1101/2023.07.11.548497
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