Article

Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease

2024-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Infections with Trypanosoma cruzi cause Chagas disease, a chronic condition that can give rise to debilitating cardiac and/or gastrointestinal damage. However, it is unclear why only ∼30% of individuals progress to symptomatic pathology, why this can take decades to become apparent, and why there is such a wide range of disease outcomes. Disease pathology is a long-term cumulative process resul...

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Literature Corpus work: 060ee7ce-1eb4-5475-b97e-340e42ecc65c
DOI: 10.1101/2024.12.03.626632

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