Bioluminescence imaging of chronic <scp> <i>T</i> </scp> <i>rypanosoma cruzi</i> infections reveals tissue‐specific parasite dynamics and heart disease in the absence of locally persistent infection

Abstract excerpt

Chronic Trypanosoma cruzi infections lead to cardiomyopathy in 20-30% of cases. A causal link between cardiac infection and pathology has been difficult to establish because of a lack of robust methods to detect scarce, focally distributed parasites within tissues. We developed a highly sensitive bioluminescence imaging system based on T. cruzi expressing a novel luciferase that emits tissue-penetrating...

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