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Article

Melanocortin-1 receptor signaling markedly induces the expression of the NR4A nuclear receptor subgroup in melanocytic cells.

The Journal of biological chemistry - 2 May 2008

Smith Aaron G, Luk Nicole, Newton Richard A, Roberts Donald W, Sturm Richard A, Muscat George E O

Abstract excerpt

The melanocortin-1 receptor (MCIR) is a G-protein-coupled receptor expressed primarily in melanocytes and is known to play a pivotal role in the regulation of pigmentation in mammals. In humans MC1R has been found to be highly polymorphic with several functional variants associated with the phenotype of red hair color and fair skin, cutaneous UV sensitivity, and increased risk of developing melanoma and...

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Share to Melanocytes
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Gene Expression Regulation, Neoplastic

Share to Receptor Cross-Talk

Share to Receptor, Melanocortin, Type 1

Share to Receptors, Cytoplasmic and Nuclear

Share to Receptors, Steroid

Source

Identifiers

PMID: 18292087
DOI: 10.1074/jbc.M800480200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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