Article

Permethylation of ribonucleosides provides enhanced mass spectrometry quantification of post-transcriptional modifications

2022-01-27

Abstract excerpt

Chemical modifications of RNA are associated with fundamental biological processes such as RNA splicing, export, translation, degradation, as well as human disease states such as cancer. However, the analysis of ribonucleoside modifications is impeded due to the hydrophilicity of the ribonucleoside molecules. In this research, we used solid-phase permethylation to derivatize the ribonucleosides, and the permethyla...

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Literature Corpus work: b297270c-7b1c-5ea5-9d4b-49689e2b0e79
DOI: 10.1101/2022.01.26.477959

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