Article

Detection of oncometabolites 1-methylnicotinamide, nicotine imine and N-Methylnicotinium in nails of oral cancer patients and prediction of them as modulators of DNMT1

2020-09-22

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The prominent among various existing views on the role of nicotine and nicotine-metabolized products in Oral squamous cell carcinoma (OSSC) is metabolic adaptation that allows the use of methyl-donor S-adenosylmethionine (SAM) for non-epigenetic purpose including the methylation of nicotinamide and nicotine. In fact, channeling of SAM for generation of 1-methylnicotinamide (1-...

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Literature Corpus work: 703c0f41-1468-59d8-b555-983595efbc57
DOI: 10.1101/2020.09.20.20198101

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