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Article

Determining RNA Natural Modifications and Nucleoside Analog-Labeled Sites by a Chemical/Enzyme-Induced Base Mutation Principle.

Molecules (Basel, Switzerland) - 4 Feb 2023

Bao Ziming, Li Tengwei, Liu Jianzhao

Abstract excerpt

The natural chemical modifications of messenger RNA (mRNA) in living organisms have shown essential roles in both physiology and pathology. The mapping of mRNA modifications is critical for interpreting their biological functions. In another dimension, the synthesized nucleoside analogs can enable chemical labeling of cellular mRNA through a metabolic pathway, which facilitates the study of RNA dynamics in a...

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PMID: 36838506
DOI: 10.3390/molecules28041517
PMCID: PMC9958784

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