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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activity

2024-10-05

Abstract excerpt

<h4>Background</h4> Angiotensin-Converting Enzyme 2 (ACE2) is a crucial peptidase in human peptide hormone signaling, catalyzing the conversion of Angiotensin-II to Angiotensin-(1-7), which activates the Mas receptor and elicits vasodilation, increased blood flow, reduced inflammation, and decreased pathological tissue remodeling. This study leverages protein engineering to enhance ACE2’s therapeutic potential fo...

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Literature Corpus work
1bb27f0d-2559-59c0-8f19-851719f86e0d
DOI
10.1101/2024.10.04.616690
Open publication

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Droplet microfluidic screening to engineer angiotensin-converting enzyme 2 (ACE2) catalytic activityDOI 10.1101/2024.10.04.616690
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