Article

Multimerin1, not Galectin-8, Promotes Gastric Chief Cell Differentiation by Tempering WNT Signaling

2025-11-05

Abstract excerpt

Galectins are a family of proteins that bind galactose-containing glycans. One member, galectin-8, preferentially binds galactose that contains a terminal sulfate. Aberrant expression and secretion of sulfated glycosylation epitopes, such as 3’-Sulfo-Le A/C , is a feature of high-risk human foregut metaplasias. In addition, recent work has demonstrated that 3’-Sulfo-Le C is a marker of mature murine zymogenic ch...

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Literature Corpus work: b2712388-22d3-5844-a1f1-29804d8df0e6
DOI: 10.1101/2025.11.04.685347

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