Article
Secretory cell hyperplasia and defects in Notch activity in a mouse model of leukocyte adhesion deficiency type II.
Gastroenterology - 1 Mar 2010
Waterhouse Christopher C M, Johnson Steven, Phillipson Mia, Zbytnuik Lori, Petri Björn, Kelly Margaret, Lowe John B, Kubes Paul
Abstract excerpt
BACKGROUND & AIMS: Leukocyte adhesion deficiency II (LAD II) is a rare condition caused by defective protein fucosylation, causing decreased leukocyte rolling, psychomotor retardation, and poor growth. The ligand-binding activity of Notch, a gastrointestinal signaling protein, depends on O-fucosylation. We investigated Notch signaling and intestinal epithelial architecture in a mouse model of LAD II. METHODS:...
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