Article

Mutation of the Galectin-3 Glycan Binding Domain ( <i>Lgals3</i> -R200S) Enhances Cortical Bone Expansion in Male and Trabecular Bone Mass in Female Mice

2020-01-09

Abstract excerpt

The study of galectin-3 is complicated by its ability to function both intracellularly and extracellularly. While the mechanism of galectin-3 secretion is unclear, studies have shown that the mutation of a highly conserved arginine to a serine in human galectin-3 ( LGALS3 -R186S) blocks glycan binding and secretion. To gain insight into the roles of extracellular and intracellular functions of galectin-3, we gene...

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Literature Corpus work: 039f210b-b5c3-59e7-99fe-b210c1919713
DOI: 10.1101/2020.01.09.900787

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