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Article

Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.

American journal of physiology. Gastrointestinal and liver physiology - 15 Sept 2012

Veniaminova Natalia A, Hayes Michael M, Varney Jessica M, Merchant Juanita L

Abstract excerpt

Antral gastrin is the hormone known to stimulate acid secretion and proliferation of the gastric corpus epithelium. Patients with mutations in the multiple endocrine neoplasia type 1 (MEN1) locus, which encodes the protein menin, develop pituitary hyperplasia, insulinomas, and gastrinomas in the duodenum. We previously hypothesized that loss of menin leads to derepression of the gastrin gene and hypergastrinemia....

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Identifiers

PMID: 22766853
DOI: 10.1152/ajpgi.00109.2012
PMCID: PMC3468536

Genes

MEN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia.PMID 22766853Read ↗

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