Article
The Alzheimer-like phosphorylation of tau protein reduces microtubule binding and involves Ser-Pro and Thr-Pro motifs.
FEBS letters - 28 Jul 1992
Gustke N, Steiner B, Mandelkow E M, Biernat J, Meyer H E, Goedert M, Mandelkow E
Abstract excerpt
Tau protein can be transformed into an Alzheimer-like state by phosphorylation with a kinase activity from brain [Biernat et al. (1992) EMBO J. 11, 1593-1597]. Here we show that the phosphorylation at Ser-Pro motifs strongly decreases tau's affinity for microtubules. The major reduction occurs du...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Brain
- Chromatography, High Pressure Liquid
- Electrophoresis, Polyacrylamide Gel
- Humans
- Microtubules
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Proline
- Protein Binding