Article

SHIP2 controls matrix mineralization by regulation of the RhoA/ROCK pathway and remodeling of the actin cytoskeleton

2022-10-31

Abstract excerpt

Mutations in INPPL1 , the gene coding for SH2 Domain-Containing Inositol 5’-Phosphatase 2 (SHIP2), cause Opsismodysplasia, a severe chondrodysplasia characterized by delayed bone maturation. The mechanism by which the loss of an inositol phosphatase causes a major skeletal developmental defect is unclear. To investigate the role of SHIP2 in mineralization, the INPPL1 gene was deleted in vitro in chondrocyte and...

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Literature Corpus work: 59e21a2d-e05c-59d0-a7d7-236a3ea69a5e
DOI: 10.1101/2022.10.30.514432

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