Article

Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach

2024-01-13

Abstract excerpt

Polygenic Scores (PGSs) summarize an individual’s genetic propensity for a given trait in a single value based on SNP effect sizes derived from Genome-Wide Association Study (GWAS) results. Methods have been developed that apply Bayesian approaches to improve the prediction accuracy of PGSs through optimization of estimated effect sizes. While these methods are generally well-calibrated for continuous traits (impl...

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Literature Corpus work: b24c79da-cdf4-5ae0-bcc6-b608e7e080c9
DOI: 10.1101/2024.01.12.24301157

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