Article

Time-resolved FRET screening identifies small molecular modifiers of mutant Huntingtin conformational inflexibility in patient-derived cells

2021-01-18

Abstract excerpt

Huntington’s disease (HD) is the most common monogenic neurodegenerative disease and is fatal. CAG repeat expansions in mutant Huntingtin (mHTT) exon 1 encode for polyglutamine (polyQ) stretches and influence age of onset and disease severity, depending on their length. mHTT is more structured compared to wild-type (wt) HTT, resulting in a decreased N-terminal conformational flexibility. mHTT inflexibility may con...

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Literature Corpus work: b80c187f-8c5f-5c62-a6c3-5d575abb3333
DOI: 10.1101/2021.01.18.427095

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