Article

A phosphorylation–deubiquitination circuit drives spatial reorganization of perinucleolar heterochromatin to restrain tumor immunogenicity

2026-04-22

Abstract excerpt

<title>Abstract</title> <p>Subnuclear compartmentalization has emerged as a critical determinant of transcriptional homeostasis and cell-fate determination. The nucleolus scaffolds specialized heterochromatin, yet the mechanisms orchestrating its spatial assembly and therapeutic relevance remain elusive. Here we identify the nucleolar deubiquitinase OTUD4 as a key coordinator of heterochromatin architecture. We d...

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Literature Corpus work: b2335164-a063-5d6c-89f5-2cc8423f943e
DOI: 10.21203/rs.3.rs-8897065/v1

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