Article
OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity.
Nature communications - 21 Aug 2020
Li Fangzhou, Sun Qianqian, Liu Kun, Zhang Ling, Lin Ning, You Kaiqiang, Liu Mingwei, Kon Ning, Tian Feng, Mao Zebin, Li Tingting, Tong Tanjun, Qin Jun, Gu Wei, Li Dawei, Zhao Wenhui
Abstract excerpt
Oncogenic processes exert their greatest effect by targeting regulators of cell proliferation. Studying the mechanism underlying growth augmentation is expected to improve clinical therapies. The ovarian tumor (OTU) subfamily deubiquitinases have been implicated in the regulation of critical cell-signaling cascades, but most OTUs functions remain to be investigated. Through an unbiased RNAi screen, knockdown of...
Topics
- Animals
- Cell Line, Tumor
- Cell Proliferation
- DNA-Binding Proteins
- Disease Models, Animal
- Female
- Gene Expression Regulation, Neoplastic
- Gene Knockdown Techniques
- Genetic Predisposition to Disease