Nucleolar stress-induced heterochromatin disengagement triggers tumour intrinsic immunogenicity

Abstract excerpt

<title>Abstract</title> <p>Various cellular stresses release immunogenic molecules and elicit immunosurveillance to detect and eliminate potential threats, thus safeguarding organismal health. Nucleolar stress is characterized by the disruption of nucleolar morphology and function, leading to impaired ribosome biogenesis and activation of stress response pathways. However, the regulatory mechanisms linking nucleo...

Topics

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• beta Catenin
• Cell Nucleolus
• Gene Knockout Techniques
• Multiple Myeloma Research and Treatments
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• RNA modifications and cancer
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

757e356b-69a3-56cb-a1b5-dd7aa40d0f68

DOI

10.21203/rs.3.rs-6101102/v1