Article
LplA1-dependent utilization of host lipoyl peptides enables Listeria cytosolic growth and virulence.
Molecular microbiology - 1 Nov 2007
Keeney Kristie M, Stuckey Jeanne A, O'Riordan Mary X D
Abstract excerpt
The bacterial pathogen Listeria monocytogenes replicates within the cytosol of mammalian cells. Mechanisms by which the bacterium exploits the host cytosolic environment for essential nutrients are poorly defined. L. monocytogenes is a lipoate auxotroph and must scavenge this critical cofactor, using lipoate ligases to facilitate attachment of the lipoyl moiety to metabolic enzyme complexes. Although the L....
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