Article
The metabolic regulator CodY links Listeria monocytogenes metabolism to virulence by directly activating the virulence regulatory gene prfA.
Molecular microbiology - 1 Feb 2015
Lobel Lior, Sigal Nadejda, Borovok Ilya, Belitsky Boris R, Sonenshein Abraham L, Herskovits Anat A
Abstract excerpt
Metabolic adaptations are critical to the ability of bacterial pathogens to grow within host cells and are normally preceded by sensing of host-specific metabolic signals, which in turn can influence the pathogen's virulence state. Previously, we reported that the intracellular bacterial pathogen Listeria monocytogenes responds to low availability of branched-chain amino acids (BCAAs) within mammalian cells by...
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