Article

Crosstalk between the glucocorticoid and mineralocorticoid receptor boosts glucocorticoid-induced killing of multiple myeloma cells

2023-05-12

Abstract excerpt

The glucocorticoid receptor (GR) is a crucial drug target in multiple myeloma as its activation with glucocorticoids effectively triggers myeloma cell death. However, as high-dose glucocorticoids are also associated with deleterious side effects, novel approaches are urgently needed to improve GR action in myeloma. Here we reveal a functional crosstalk between GR and the mineralocorticoid receptor (MR) that culmin...

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Literature Corpus work: 6d11cab0-9798-56b3-916b-3bc3658055a1
DOI: 10.1101/2023.05.10.540157

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