Article

Differential PARP inhibitor responses in <i>BRCA1</i> -deficient and resistant cells in competitive co-culture

2025-05-02

Abstract excerpt

Synthetic lethality describes a genetic relationship where the loss of two genes results in cell death, but the loss of one of those genes does not. Drugs used for precision oncology can exploit synthetic lethal relationships; the best described are PARP inhibitors which preferentially kill BRCA1 -deficient tumours preferentially over BRCA1 -proficient cells. New synthetic lethal targets are often discovered usi...

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Literature Corpus work: b203d26f-b55d-5dc0-a018-1a0ef8795671
DOI: 10.1101/2025.05.02.651448

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