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Article

Unmatched Cell Line Collections Are Not Optimal for Identification of PARP Inhibitor Response and Drug Synergies.

Journal of cellular and molecular medicine - 1 Sept 2025

Phan Zoe, Fernandez Kristine J, Caldon C Elizabeth

Abstract excerpt

PARP inhibitors show great efficacy in BRCA1/2-mutated patients, but many preclinical studies, including combination therapies, fail to translate clinically, likely due to the limitations of preclinical models. This brief report aimed to identify appropriate cell line models to investigate PARP inhibitor sensitivity and synergies. An in silico study of cell line collections was performed to assess the correlation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40977519
DOI: 10.1111/jcmm.70845
PMCID: PMC12451393

Genes

BRCA1
BRCA2
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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