Article
Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors.
Annual review of medicine - 1 Jan 2015
Lord Christopher J, Tutt Andrew N J, Ashworth Alan
Abstract excerpt
The genetic concept of synthetic lethality, in which the combination or synthesis of mutations in multiple genes results in cell death, provides a framework to design novel therapeutic approaches to cancer. Already there are promising indications, from clinical trials exploiting this concept by using poly(ADP-ribose) polymerase (PARP) inhibitors in patients with germline BRCA1 or BRCA2 gene mutations, that this...
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