Article

Unmatched cell line collections are not optimal for identification of PARP inhibitor response and drug synergies

2025-05-01

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> While PARP inhibitors have shown great efficacy in patients with BRCA1 and BRCA2 mutations, many preclinical studies, including combination therapies, fail to translate into clinical approval, potentially due to the limitations of preclinical models. The goal of this brief report was to identify appropriate cell line models to investigate PARP inhibitor sensitivity and synerg...

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Literature Corpus work: acfe877b-54b3-56f7-8483-6ca64982a863
DOI: 10.1101/2025.04.28.650908

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