Article

CRISPR Double Knockout Library Reveals Synthetic Lethal Gene Pairs in Triple-Negative Breast Cancer

2024-05-17

Abstract excerpt

Synthetic lethality, a genetic interaction involving two or more genes whose combined loss results in cell death, has emerged as a promising strategy for targeted cancer therapy. By exploiting synthetic lethal interactions, cancer cells can be selectively targeted and eradicated while preserving healthy cells, minimizing off-target effects, and reducing toxicity. The development of PARP inhibitors for ovarian and...

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Literature Corpus work: 09ef58c7-f9f4-5c1d-8909-2bfaaeb7acdb
DOI: 10.1101/2024.05.14.594157

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