Article

Vector and cell-culture passaging of dengue clinical samples for virus isolation and amplification does not significantly change genome consensus or frequencies of intra-host viral variants

2020-08-18

Abstract excerpt

<h4>ABSTRACT</h4> Intra-host single nucleotide variants (iSNVs) have been increasingly used in genomic epidemiology to increase phylogenetic resolution and reconstruct fine-scale outbreak dynamics. These analyses are preferably done on sequence data from direct clinical samples, but in many cases due to low viral loads, there might not be enough genetic material for deep sequencing and iSNV determination. Isolati...

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Literature Corpus work: b200da66-2d33-5a0d-afa3-19292c00d8e7
DOI: 10.1101/2020.08.17.254417

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