Article
Effect of low-passage number on dengue consensus genomes and intra-host variant frequencies.
The Journal of general virology - 1 Mar 2021
Fung Christian K, Li Tao, Pollett Simon, Alera Maria Theresa, Yoon In-Kyu, Hang Jun, Macareo Louis, Srikiatkhachorn Anon, Ellison Damon, Rothman Alan L, Fernandez Stefan, Jarman Richard G, Maljkovic Berry Irina
Abstract excerpt
Intra-host single nucleotide variants (iSNVs) have been increasingly used in genomic epidemiology to increase phylogenetic resolution and reconstruct fine-scale outbreak dynamics. These analyses are preferably done on sequence data from direct clinical samples, but in many cases due to low viral loads, there might not be enough genetic material for deep sequencing and iSNV determination. Isolation of the virus...
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