Article
Inter- and intra-host viral diversity in a large seasonal DENV2 outbreak.
PloS one - 1 Jan 2013
Romano Camila Malta, Lauck Michael, Salvador Felipe S, Lima Célia Rodrigues, Villas-Boas Lucy S, Araújo Evaldo Stanislau A, Levi José Eduardo, Pannuti Claudio Sergio, O'Connor David, Kallas Esper Georges
Abstract excerpt
BACKGROUND: High genetic diversity at both inter- and intra-host level are hallmarks of RNA viruses due to the error-prone nature of their genome replication. Several groups have evaluated the extent of viral variability using different RNA virus deep sequencing methods. Although much of this effort has been dedicated to pathogens that cause chronic infections in humans, few studies investigated arthropod-borne,...
Topics
- Adult
- Aged
- Aged, 80 and over
- Dengue
- Dengue Virus
- Disease Outbreaks
- Female
- Genetic Variation
- Genome, Viral
- High-Throughput Nucleotide Sequencing
- Humans