Article

Prognostic Stratification for IDH-wild-type Lower-grade Astrocytoma by Sanger Sequencing and Copy-number Variation Analysis with MLPA.

2021-02-16

Abstract excerpt

The characteristics of IDH -wild-type lower-grade astrocytoma remain unclear. According to cIMPACT-NOW update 3, IDH -wild-type astrocytomas with any of the following factors show poor prognosis: combination of chromosome 7 gain and 10 loss (+ 7/-10), and/or EGFR amplification, and/or TERT promoter ( TERT p) mutation. Multiplex ligation-dependent probe amplification (MLPA) can detect copy number variations with a...

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Literature Corpus work: b1d819ae-3529-571b-9a7c-ee94dc87dcad
DOI: 10.21203/rs.3.rs-198063/v1

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