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Mismatch repair proteins PMS2 and MLH1 can further refine molecular stratification of IDH-mutant lower grade astrocytomas.

Clinical neurology and neurosurgery - 1 Sept 2021

Yang Rui Ryan, Li Kay Ka-Wai, Zhang Zhen-Yu, Chan Aden Ka-Yin, Wang Wei-Wei, Chan Danny Tat-Ming, Li Wen-Cai, Liu Xian-Zhi, Li Fang-Cheng, Chen Hong, Ng Ho-Keung, Mao Ying, Shi Zhi-Feng

Abstract excerpt

The diagnostic role of Isocitrate Dehydrogenase (IDH) mutation status in adult lower grade astrocytomas was first formally presented within the WHO Classification of Tumours of the Central Nervous System (2016). IDH-mutant astrocytomas are not as common as IDH-wildtype astrocytomas but are of better prognosis. Our previous study provided an evident that IDH-mutant lower grade astrocytomas is not a homogeneous...

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PMID: 34428613
DOI: 10.1016/j.clineuro.2021.106882

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