Article
A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation.
Nature genetics - 1 Oct 2012
Jenkins Robert B, Xiao Yuanyuan, Sicotte Hugues, Decker Paul A, Kollmeyer Thomas M, Hansen Helen M, Kosel Matthew L, Zheng Shichun, Walsh Kyle M, Rice Terri, Bracci Paige, McCoy Lucie S, Smirnov Ivan, Patoka Joseph S, Hsuang George, Wiemels Joe L, Tihan Tarik, Pico Alexander R, Prados Michael D, Chang Susan M, Berger Mitchel S, Caron Alissa A, Fink Stephanie R, Halder Chandralekha, Rynearson Amanda L, Fridley Brooke L, Buckner Jan C, O'Neill Brian P, Giannini Caterina, Lachance Daniel H, Wiencke John K, Eckel-Passow Jeanette E, Wrensch Margaret R
Abstract excerpt
Variants at 8q24.21 have been shown to be associated with glioma development. By means of tag SNP genotyping and imputation, pooled next-generation sequencing using long-range PCR and subsequent validation SNP genotyping, we identified seven low-frequency SNPs at 8q24.21 that were strongly associated with glioma risk (P=1×10(-25) to 1×10(-14)). The most strongly associated SNP, rs55705857, remained highly...
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