Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Adult IDH wild-type lower-grade gliomas should be further stratified.

Neuro-oncology - 1 Oct 2017

Aibaidula Abudumijit, Chan Aden Ka-Yin, Shi Zhifeng, Li Yanxi, Zhang Ruiqi, Yang Rui, Li Kay Ka-Wai, Chung Nellie Yuk-Fei, Yao Yu, Zhou Liangfu, Wu Jinsong, Chen Hong, Ng Ho-Keung

Abstract excerpt

BACKGROUND: Astrocytoma of the isocitrate dehydrogenase (IDH) wild-type gene is described as a provisional entity within the new World Health Organization (WHO) classification. Some groups believe that IDH wild-type lower-grade gliomas, when interrogated for other biomarkers, will mostly turn out to be glioblastoma. We hypothesize that not all IDH wild-type lower-grade gliomas have very poor outcomes and the...

Topics

Join the communities discussing this publication.

Aged
Biomarkers, Tumor
Brain Neoplasms
Genetic Predisposition to Disease
Glioma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Isocitrate Dehydrogenase

Neoplasm Grading

Source

Open in PubMed Open full text

Identifiers

PMID: 28575485
DOI: 10.1093/neuonc/nox078
PMCID: PMC5596181

Genes

EGFR
MYB
BRAF
IDH1
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adult IDH wild-type lower-grade gliomas should be further stratified.PMID 28575485Read ↗

IDH mutant lower grade (WHO Grades II/III) astrocytomas can be stratified for risk by CDKN2A, CDK4 and PDGFRA copy number alterations.Semantic proximity Read ↗

Molecular Characterization of “True” Low-Grade IDH-Wildtype AstrocytomasSemantic proximity Read ↗

IDH-wildtype lower-grade diffuse gliomas: the importance of histological grade and molecular assessment for prognostic stratification.Semantic proximity Read ↗

Comparison between molecular and histological IDH-wild-type glioblastoma and extensive subgroup analysis of IDH-wild-type astrocytic tumors without genomic glioblastoma-defining alterations.Semantic proximity Read ↗

IDH wild-type lower-grade gliomas with glioblastoma molecular features: a systematic review and meta-analysis.Semantic proximity Read ↗

Molecular Correlates of Long Survival in IDH-Wildtype Glioblastoma CohortsSemantic proximity Read ↗

Comparative Analysis of the Prognostic Significance of IDH,TERT, EGFR and MGMT Status in Patients with Adult Non-H3-Altered Grade 4 Gliomas: A Prospective Cohort Study.Semantic proximity Read ↗

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.Semantic proximity Read ↗

Management for Different Glioma Subtypes: Are All Low-Grade Gliomas Created Equal?Semantic proximity Read ↗

Clinico-neuropathological features of isocitrate dehydrogenase 2 gene mutations in lower-grade gliomas.Semantic proximity Read ↗

Adult IDH wild type astrocytomas biologically and clinically resolve into other tumor entities.Semantic proximity Read ↗

IDH-mutant grade 4 astrocytoma: a comparison integrating the clinical, pathological, and survival features between primary and secondary patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.