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Article

Optimizing the risk stratification of astrocytic tumors by applying the cIMPACT-NOW Update 3 signature: real-word single center experience.

Scientific reports - 16 Nov 2023

Molica Carmen, Gili Alessio, Nardelli Carlotta, Pierini Tiziana, Arniani Silvia, Beacci Donatella, Mavridou Elena, Mandarano Martina, Corinaldesi Rodolfo, Metro Giulio, Gorello Paolo, Giovenali Paolo, Cenci Nunzia, Castrioto Corrado, Lupattelli Marco, Roila Fausto, Mecucci Cristina, La Starza Roberta

Abstract excerpt

Our work reports implementation of a useful genetic diagnosis for the clinical managment of patients with astrocytic tumors. We investigated 313 prospectively recruited diffuse astrocytic tumours by applying the cIMPACT-NOW Update 3 signature. The cIMPACT-NOW Update 3 (cIMPACT-NOW 3) markers, i.e., alterations of TERT promoter, EGFR, and/or chromosome 7 and 10, characterized 96.4% of IDHwt cases. Interestingly,...

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Identifiers

PMID: 37973912
DOI: 10.1038/s41598-023-46701-z
PMCID: PMC10654668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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