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Article

Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA.

Scientific reports - 13 Jul 2021

Makino Yasuhide, Arakawa Yoshiki, Yoshioka Ema, Shofuda Tomoko, Kawauchi Takeshi, Terada Yukinori, Tanji Masahiro, Kanematsu Daisuke, Mineharu Yohei, Miyamoto Susumu, Kanemura Yonehiro

Abstract excerpt

The characteristics of IDH-wild-type lower-grade astrocytoma remain unclear. According to cIMPACT-NOW update 3, IDH-wild-type astrocytomas with any of the following factors show poor prognosis: combination of chromosome 7 gain and 10 loss (+ 7/- 10), and/or EGFR amplification, and/or TERT promoter (TERTp) mutation. Multiplex ligation-dependent probe amplification (MLPA) can detect copy number alterations at...

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Identifiers

PMID: 34257410
DOI: 10.1038/s41598-021-93937-8
PMCID: PMC8277860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA.PMID 34257410Read ↗

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