TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma.

doi:10.1007/s00401-021-02337-9

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Article

TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma.

Acta neuropathologica - 1 Aug 2021

Fujimoto Kenji, Arita Hideyuki, Satomi Kaishi, Yamasaki Kai, Matsushita Yuko, Nakamura Taishi, Miyakita Yasuji, Umehara Toru, Kobayashi Keiichi, Tamura Kaoru, Tanaka Shota, Higuchi Fumi, Okita Yoshiko, Kanemura Yonehiro, Fukai Junya, Sakamoto Daisuke, Uda Takehiro, Machida Ryunosuke, Kuchiba Aya, Maehara Taketoshi, Nagane Motoo, Nishikawa Ryo, Suzuki Hiroyoshi, Shibuya Makoto, Komori Takashi, Narita Yoshitaka, Ichimura Koichi

Abstract excerpt

The Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy (cIMPACT-NOW) update 3 recommends that histologic grade II and III IDH-wildtype diffuse astrocytic gliomas that harbor EGFR amplification, the combination of whole chromosome 7 gain and whole chromosome 10 loss (7 + /10 -), or TERT promoter (pTERT) mutations should be considered as glioblastomas (GBM), World Health Organization...

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PMID: 34148105
DOI: 10.1007/s00401-021-02337-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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TERT promoter mutation status is necessary and sufficient to diagnose IDH-wildtype diffuse astrocytic glioma with molecular features of glioblastoma.PMID 34148105Read ↗

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