Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and functional consequences of non-synonymous SNPs within the LAMA2 protein: a molecular dynamics perspective.

Journal of biomolecular structure & dynamics - 1 Feb 2026

Ali Rafat, Sultan Armiya, Ishrat Romana, Saini Deeksha, Hayat Shaheen, Khan Nida Jamil

Abstract excerpt

Clinical phenotypic presentations associated with LAMA2 deficiency have shown a variety of manifestations. LAMA2 mutations are mainly linked to congenital muscular dystrophy, but there is also mounting evidence suggesting their presence in inflammatory breast cancer, laryngopharyngeal squamous cell carcinoma, and ventricular tachycardia related to coronary artery disease and cardiomyopathy. This study examined...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to LAMA2 gene
Share to Hydrogen Bonding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Laminin

Share to Molecular Dynamics Simulation

Share to Mutation

Share to Polymorphism, Single Nucleotide

Share to Protein Conformation

Share to Structure-Activity Relationship

Source

Identifiers

PMID: 39522170
DOI: 10.1080/07391102.2024.2426756

Genes

LAMA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and functional consequences of non-synonymous SNPs within the LAMA2 protein: a molecular dynamics perspective.PMID 39522170Read ↗

Exploring the structural insights on human laforin mutation K87A in Lafora disease--a molecular dynamics study.Semantic proximity Read ↗

A Novel LAMA2 Mutation (c.7412G>A) Was Found in a Chinese Patient With Congenital Muscular Dystrophy.Semantic proximity Read ↗

Whole-exome analyses of congenital muscular dystrophy and congenital myopathy patients from India reveal a wide spectrum of known and novel mutations.Semantic proximity Read ↗

Three novel recessive mutations in LAMA2, SYNE1, and TTN are identified in a single case with congenital muscular dystrophy.Semantic proximity Read ↗

Genetic profile of Brazilian patients with LAMA2-related dystrophies.Semantic proximity Read ↗

Clinical and genomic characteristics of LAMA2 related congenital muscular dystrophy in a patients’ cohort from Qatar. A population specific founder variantSemantic proximity Read ↗

Interpreting the molecular mechanisms of disease variants in human transmembrane proteinsSemantic proximity Read ↗

Structural Analysis of G1691S Variant in the Human Filamin B Gene Responsible for Larsen Syndrome: A Comparative Computational Approach.Semantic proximity Read ↗

Novel Mutation (c.8725T>C) in Two Siblings With Late-Onset LAMA2-Related Muscular Dystrophy.Semantic proximity Read ↗

Merosin-deficient congenital muscular dystrophy: A novel homozygous mutation in the laminin-2 gene.Semantic proximity Read ↗

An Integrated Computational Framework to Assess the Mutational Landscape of α-L-Iduronidase IDUA Gene.Semantic proximity Read ↗

Elucidating the functional impact of G137V and G144R variants in Maroteaux Lamy's Syndrome by Molecular Dynamics Simulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.