Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement.

Proceedings of the National Academy of Sciences of the United States of America - 20 Aug 1996

Lorenzi M V, Horii Y, Yamanaka R, Sakaguchi K, Miki T

Abstract excerpt

A constitutively active form of fibroblast growth factor 2 (FGFR2) was identified in rat osteosarcoma (ROS) cells by an expression cloning strategy. Unlike other tyrosine kinase receptors activated by N-terminal truncation in tumors, this receptor, FGFR2-ROS, contains an altered C terminus generated from chromosomal rearrangement with a novel gene, designated FGFR activating gene 1 (FRAG1). While the removal of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Binding Sites

Share to Cloning, Molecular

Share to Molecular Sequence Data

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 8799135
DOI: 10.1073/pnas.93.17.8956
PMCID: PMC38576

Genes

FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

FRAG1, a gene that potently activates fibroblast growth factor receptor by C-terminal fusion through chromosomal rearrangement.PMID 8799135Read ↗

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations.Semantic proximity Read ↗

FGFR rearrangements: oncogenic drivers and therapeutic targets.Semantic proximity Read ↗

FGFR families: biological functions and therapeutic interventions in tumorsSemantic proximity Read ↗

The C-Terminal Kinase Domain-Binding and Suppression Motif Prevents Constitutive Activation of FGFR2.Semantic proximity Read ↗

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review).Semantic proximity Read ↗

Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2.Semantic proximity Read ↗

Identification of a novel gene, <i>FGFR1OP2</i>, fused to <i>FGFR1</i> in 8p11 myeloproliferative syndromeSemantic proximity Read ↗

GPER Mediates a Feedforward FGF2/FGFR1 Paracrine Activation Coupling CAFs to Cancer Cells toward Breast Tumor ProgressionSemantic proximity Read ↗

Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells.Semantic proximity Read ↗

Role of Fra-2 in cancerSemantic proximity Read ↗

A truncated derivative of FGFR1 kinase cooperates with FLT3 and KIT to transform hematopoietic stem cells in syndromic and de novo AMLSemantic proximity Read ↗

Complexity of FGF receptors: genetic basis for structural diversity and functional specificity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.