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Article

The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes.

PloS one - 1 Jan 2011

Belleudi Francesca, Purpura Valeria, Torrisi Maria Rosaria

Abstract excerpt

The FGFRs trigger divergent responses, such as proliferation and differentiation, and the cell type as well as the context-dependent signaling are crucial for the functional outcome. The FGFR2b/KGFR is expressed exclusively on epithelial cells and plays a key role in skin homeostasis. Here we analyzed in vitro the role of KGFR in the early differentiation of keratinocytes modulating its expression by KGFR cDNA...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Mutagenesis

Share to Phosphatidylinositol 3-Kinases

Share to Protein Kinase Inhibitors

Share to Proto-Oncogene Proteins c-akt

Share to Receptor, Fibroblast Growth Factor, Type 2

Source

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Identifiers

PMID: 21957444
DOI: 10.1371/journal.pone.0024194
PMCID: PMC3177842

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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