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Article

High genetic barrier to SARS-CoV-2 polyclonal neutralizing antibody escape.

Nature - 1 Dec 2021

Schmidt Fabian, Weisblum Yiska, Rutkowska Magdalena, Poston Daniel, DaSilva Justin, Zhang Fengwen, Bednarski Eva, Cho Alice, Schaefer-Babajew Dennis J, Gaebler Christian, Caskey Marina, Nussenzweig Michel C, Hatziioannou Theodora, Bieniasz Paul D

Abstract excerpt

The number and variability of the neutralizing epitopes targeted by polyclonal antibodies in individuals who are SARS-CoV-2 convalescent and vaccinated are key determinants of neutralization breadth and the genetic barrier to viral escape1-4. Using HIV-1 pseudotypes and plasma selection experiments with vesicular stomatitis virus/SARS-CoV-2 chimaeras5, here we show that multiple neutralizing epitopes, within and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34544114
DOI: 10.1038/s41586-021-04005-0
PMCID: PMC9241107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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