Article
Total zinc intake may modify the glucose-raising effect of a zinc transporter (SLC30A8) variant: a 14-cohort meta-analysis.
Diabetes - 1 Sept 2011
Kanoni Stavroula, Nettleton Jennifer A, Hivert Marie-France, Ye Zheng, van Rooij Frank J A, Shungin Dmitry, Sonestedt Emily, Ngwa Julius S, Wojczynski Mary K, Lemaitre Rozenn N, Gustafsson Stefan, Anderson Jennifer S, Tanaka Toshiko, Hindy George, Saylor Georgia, Renstrom Frida, Bennett Amanda J, van Duijn Cornelia M, Florez Jose C, Fox Caroline S, Hofman Albert, Hoogeveen Ron C, Houston Denise K, Hu Frank B, Jacques Paul F, Johansson Ingegerd, Lind Lars, Liu Yongmei, McKeown Nicola, Ordovas Jose, Pankow James S, Sijbrands Eric J G, Syvänen Ann-Christine, Uitterlinden André G, Yannakoulia Mary, Zillikens M Carola, Wareham Nick J, Prokopenko Inga, Bandinelli Stefania, Forouhi Nita G, Cupples L Adrienne, Loos Ruth J, Hallmans Goran, Dupuis Josée, Langenberg Claudia, Ferrucci Luigi, Kritchevsky Stephen B, McCarthy Mark I, Ingelsson Erik, Borecki Ingrid B, Witteman Jacqueline C M, Orho-Melander Marju, Siscovick David S, Meigs James B, Franks Paul W, Dedoussis George V
Abstract excerpt
OBJECTIVE: Many genetic variants have been associated with glucose homeostasis and type 2 diabetes in genome-wide association studies. Zinc is an essential micronutrient that is important for β-cell function and glucose homeostasis. We tested the hypothesis that zinc intake could influence the glucose-raising effect of specific variants. RESEARCH DESIGN AND METHODS: We conducted a 14-cohort meta-analysis to...
Read the complete abstract on PubMed