Article
The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance.
The Journal of clinical investigation - 1 Oct 2013
Tamaki Motoyuki, Fujitani Yoshio, Hara Akemi, Uchida Toyoyoshi, Tamura Yoshifumi, Takeno Kageumi, Kawaguchi Minako, Watanabe Takahiro, Ogihara Takeshi, Fukunaka Ayako, Shimizu Tomoaki, Mita Tomoya, Kanazawa Akio, Imaizumi Mica O, Abe Takaya, Kiyonari Hiroshi, Hojyo Shintaro, Fukada Toshiyuki, Kawauchi Takeshi, Nagamatsu Shinya, Hirano Toshio, Kawamori Ryuzo, Watada Hirotaka
Abstract excerpt
Recent genome-wide association studies demonstrated that common variants of solute carrier family 30 member 8 gene (SLC30A8) increase susceptibility to type 2 diabetes. SLC30A8 encodes zinc transporter-8 (ZnT8), which delivers zinc ion from the cytoplasm into insulin granules. Although it is well known that insulin granules contain high amounts of zinc, the physiological role of secreted zinc remains elusive. In...
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