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Article

Potential positive and negative consequences of ZnT8 inhibition.

The Journal of endocrinology - 1 Aug 2020

Syring Kristen E, Bosma Karin J, Goleva Slavina B, Singh Kritika, Oeser James K, Lopez Christopher A, Skaar Eric P, McGuinness Owen P, Davis Lea K, Powell David R, O'Brien Richard M

Abstract excerpt

SLC30A8 encodes the zinc transporter ZnT8. SLC30A8 haploinsufficiency protects against type 2 diabetes (T2D), suggesting that ZnT8 inhibitors may prevent T2D. We show here that, while adult chow fed Slc30a8 haploinsufficient and knockout (KO) mice have normal glucose tolerance, they are protected against diet-induced obesity (DIO), resulting in improved glucose tolerance. We hypothesize that this protection...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32485672
DOI: 10.1530/JOE-20-0138
PMCID: PMC7351606

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