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The Tyrosine Kinome Dictates Breast Cancer Heterogeneity and Therapeutic Responsiveness

28 Mar 2016

Abstract excerpt

Phospho-tyrosine signaling networks control numerous biological processes including cellular differentiation, cell growth and survival, motility, and invasion. Aberrant regulation of the tyrosine kinome is a hallmark of malignancy and influences all stages of breast cancer progression, from initiation to the development of metastatic disease. The success of specific tyrosine kinase inhibitors strongly validates...

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PMID: 27392311
DOI: 10.1002/jcb.25561

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