Article

A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathway

2022-06-16

Abstract excerpt

Protein tyrosine phosphatase 1B (PTP1B) plays a key role in developing different types of cancer. However, the molecular mechanism underlying this effect is unclear. To identify possible molecular targets of PTP1B that mediate its positive role in tumorigenesis, we undertook a SILAC-based phosphoproteomic approach, which allowed us to identify the Cyclin-dependent kinase 3 (Cdk3) as a novel PTP1B substrate. Molecu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b188f51e-b177-5235-b035-e5b556c4517f
DOI: 10.1101/2022.06.14.496178

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A PTP1B-Cdk3 signaling axis promotes cell cycle progression of human glioblastoma cells through an Rb-E2F dependent pathwayDOI 10.1101/2022.06.14.496178Read

Protein Tyrosine Phosphatase 1B (PTP1B): Insights into its New Implications in TumorigenesisSemantic proximity Read

Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosisSemantic proximity Read

EMP3 sustains oncogenic EGFR/CDK2 signaling by restricting receptor degradation in glioblastomaSemantic proximity Read

Stabilization of GTSE1 by cyclin D1-CDK4/6-mediated phosphorylation promotes cell proliferation: relevance in cancer prognosisSemantic proximity Read

Identification of CDK1, PBK, and CHEK1 as an Oncogenic Signature in Glioblastoma: A Bioinformatics Approach to Repurpose Dapagliflozin as a Therapeutic AgentSemantic proximity Read

The tumor suppressor CDKN3 controls mitosisSemantic proximity Read

Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling.Semantic proximity Read

CDK1-mediated mitotic phosphorylation of PBK is involved in cytokinesis and inhibits its oncogenic activity.Semantic proximity Read

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survivalSemantic proximity Read

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugsSemantic proximity Read

Targeting BACH1 by HPPE inhibits the Wnt/β-catenin pathway and malignant phenotype in glioblastoma cells.Semantic proximity Read

Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility.Semantic proximity Read