Article
Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility.
Oncotarget - 30 Sept 2014
Bourgonje Annika M, Navis Anna C, Schepens Jan T G, Verrijp Kiek, Hovestad Liesbeth, Hilhorst Riet, Harroch Sheila, Wesseling Pieter, Leenders William P J, Hendriks Wiljan J A J
Abstract excerpt
Gliomas are primary brain tumors for which surgical resection and radiotherapy is difficult because of the diffuse infiltrative growth of the tumor into the brain parenchyma. For development of alternative, drug-based, therapies more insight in the molecular processes that steer this typical growth and morphodynamic behavior of glioma cells is needed. Protein tyrosine phosphatase PTPRZ-B is a transmembrane...
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